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头颈部肿瘤多药耐药机制及逆转剂研究进展

作者:鲍晓峰 张伟国
出处:论文网
时间:2007-08-31

  总之,经过对MDR机制的深入研究,现在已取得了一些重要发现,在其临床如何克服MDR方面也取得一定进展,但其效果不尽人意。而且对于头颈部肿瘤的MDR研究仍较少,有关逆转剂的报道也不多。因此,对于头颈部MDR逆转剂的研究是今后我们克服化疗耐药研究的主要方向之一。

[参考文献]

  [1] Filer JS, Underhill LH. Multiple-drug resistance in human cancer[J]. N Engl J Med, 1987, 316:1388-1393.

  [2] Ford JM. Modulators of multidrug resistance[J]. Hematol Oncol North Am, 1995, 9:337-361.

  [3] Goldstein LJ. Clinical reversal of drug resistance[J]. Curr Probl Cancer, 1995, 3:70-123.

  [4] Rabkin D, Chhieng DC, Miller MB, et al. P-glycoprotein expression in squamous cell carcinomas of the tongue base[J]. Laryngoscope, 1995, 105:1294-1299.

  [5] Kelley DJ, Pavelic ZP, Gapany M, et al. Detection of P-glycoprotein in squamous cell carcinomas of the head and neck[J]. Arch Ortolaryngol Head Neck Surg, 1993, 19:411-414.

  [6] Jain V, Das SN, Luthra K, Shukla NK, Ralhan R. Differential expression of multidrug resistance gene product, P-glycoprotein, in normal, dysplastic and malignant oral mucosa in India[J]. Int J Cancer, 1997, 74:128-133.

  [7] Yuen AR, Sikic BI. Multidrug resistance in lymphomas[J]. J Clin Onclo, 1994, 12:2453-2459.

  [8] Cheng AL, Su IJ, Chen YC, Lee TC, Wang CH. Expression of P-glycoprotein and glutathione-s-transferase in recurrent lymphomas: The possible role of epstein barr virus, immunophenotypes, and other predisposing factors[J]. J Clin Oncol, 1993, 11:109-115.

  [9] Niehans GA, Jaszcz W, Brunetto V, et al. Immunohistochemical identification of P-glycoprotein in previously untreated, diffuse large cell and immunoblastic lyphomas[J]. Cancer Res, 1992, 52:3768-3775.

  [10] Kang YK, Zhan Z, Regis J, et al. Expression of mdr-1 in refractory lymphoma: quantitation by polymerase china reaction and validation of the assay[J]. Blood, 1995, 86:1515-1524.

  [11] Perez RP, Hamilton TC, Ozols RF. Resistance to alkylating agents and cisplatin: insights from ovarian carcinoma model systems[J]. Pharmacol Ther, 1990, 48:19-27.

  [12] Bongers V, Snow GB, deVries N, et al. Second primary head and neck squamous cell carcinoma predicted by the glutathione s-transferase expression in healthy tissue in the direct vicinity of the first tumor[J]. Lab Invest, 1995,73:503-509.

  [13] Welters MJP, Fichitnger-Schepman AMJ, Baan RA, Fleno MJ, Scheper RJ, Breahhuis BJM. Role of glutathone, glutathione s-transfereases and multidrug resistance-related proteins in cisplatin sensitivity of head and neck cancer cell lines[J]. Br J Cancer, 1998, 77:556-561.

  [14] Muller M, Meijer C, Zaman GJR. et al. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione s-conjugate transport[J]. Proc Natl Acad Sci USA, 1994, 91:13033-13037.

  [15] Fisher GA, Sikic BI. Clinical studies with modulators of multidrug resistance[J]. Hematol Oncol North Am, 1995, 9:363-382.

  [16] Klopman G, Shi LM, Ramu A. Quantitative structure-activity relationship of multidrug resistance reversal agents[J]. Mol Pharmacol, 1997, 52:323-334.

  [17] Sikic BI. Modulation of multidrug resistance: at the threshold[J]. J Clin Oncol, 1993, 11:1629-1635.

  [18] Wilson WH, Jamis-Dow C, Bryant G, et al. Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy[J]. J Clin Oncol, 1995, 13: 1985-1994.

  [19] Wilson WH, Bates S, Fojo A, et al. Controlled trial of dexverapamil, a modulator of multidrug resistance, in lymphomas refractory to EPOCH chemotherapy[J]. J Clin Oncol, 1995, 13:1995-2004.

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