微生态制剂金双歧治疗喂养不耐受早产儿的观察
【关键词】 金双歧
摘要：目的：探讨喂养不耐受早产儿的治疗方法，提高早产儿的存活率。方法：76例喂养不耐受早产儿随机分为治疗组40例，对照组36例，两组均按照常规护理和治疗，并予静脉营养，治疗组在喂奶后口服或鼻饲微生态制剂金双歧三联活菌片0.5g，2次/d，疗程5d。结果：治疗组显效32例，有效7例，无效1例，总有效率97.5%；对照组显效8例，有效18例，无效10例，总有效率72.2%；两组有效率比较X2=7.84，P<0.01，差异有显著性。结论：应用微生态制剂金双歧治疗喂养不耐受早产儿效果确切,未发现不良反应，且缩短早产儿的住院时间。
关键词： 金双歧； 治疗； 喂养不耐受； 早产儿
Clinical Observation of the Therapeutic Efficacy of “GOLDEN BIFID” on Premature with Feeding Intolerance
Abstract: Objective: To observe the clinical efficacy of “Golden bifid” on the treatment of premature with feeding intolerance. Method: 76 cases of premature with feeding intolerance were assigned into two groups by randomization:the therapeutic group contained 40 cases and the control group contained 36. Both group of infants were given the routine nursery and treatment, intravenous transfusion was given as well. Moreover, the infants of the therapeutic group were extra given the “Golden bifid” (A pill of tri-covalent viable organism from Inner Mongolian Shuang Qi drug company) by oral or nasal feeding, 0.5g a time, two times a day, and the period of treatment lasted for 5 days. Result: In the therapeutic group, 32 cases showed excellence (obviously effective), 7 cases showed utility (effective) and 1 case showed ineffective, the total effective rate is 97.5%. Among the control group, 8cases showed excellence (obviously effective), 18 cases showed utility (effective) and 10 cases showed ineffective, the total effective rate is 72.2%. After comparing the effective rate of both groups (by chi-square test),X2=7.84, P<0.01, the difference is of significance. Conclusion: The clinical efficacy of “golden bifid” on the treatment of premature with feeding intolerance has been proved certainly,without side effects yet.
Key words: Golden bifid; Treatment; Feeding intolerance； Premature
由于早产儿胃肠功能极为低下，易发生腹胀、胃潴留、呕吐等喂养不耐受表现，严重影响体重回升和存活率。越来越多的研究表明，出生后早期有效的营养支持可改善早产儿近期体重增长、降低病死率，还影响到远期预后［1］。
金双歧是由长双歧杆菌、保加利亚乳杆菌、嗜热链球菌组成的三联活菌微生态制剂。本研究应用金双歧治疗喂养不耐受早产儿40例，旨在探讨喂养不耐受早产儿的治疗方法，现报道如下。
1 对象和方法
1．1 对象：2001年1月至2004年10 月在我院新生儿科住院的早产儿，选取有腹胀、胃潴留、呕吐等喂养不耐受表现者76例。其中，男45例，女31例；胎龄28～30周4例，30～34周62例，34～36周10例；体重<1500g 5例，1500～2000g62例，>2000g9例；日龄均在3d内。76例中腹胀53例，胃潴留46例，呕吐15例，随机分为两组，治疗组40例，对照组36例。两组在胎龄、出生体重、日龄及临床表现等均具有可比性（P>0.05）。所有病例均无合并症，无应用制酸药物、抗菌药物等影响微生态制剂疗效的药物，并排除消化系统器质性病变及外科情况。
1．2 方法：两组病例均按常规护理和治疗，并予静脉营养支持；治疗组于喂奶后口服或鼻饲金双歧片0.5g，2次/d，疗程5d。金双歧为内蒙古双奇药业生产的含长双歧杆菌、保加利亚乳杆菌、嗜热链球菌三联活菌片。
1．3 疗效判断：显效：腹胀、胃潴留、呕吐等症状、体征完全消失；有效：呕吐消失，腹胀、胃潴留明显改善；无效：以上症状、体征无明显改变。
